Herein, we presented an enantioselective intramolecular Diels–Alder (IMDA) reaction with vinyl branched vinylidene ortho-quinone methide (VQM). The control of site selectivity in the IMDA reaction led to both chiral bridged bicyclo[4.3.1] and [5.3.1] architectures with high isolated yields (up to 85%) and excellent enantioselectivities (up to 97% ee).
![Graphical abstract: Catalytic asymmetric construction of bridged bicyclo[m.3.1] rings using an intramolecular Diels–Alder reaction](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=D4CC02850C&imageInfo.ImageIdentifier.Year=2024)
K. Li, Z. Zhao, W. Qin, Y. Liu and H. Yan, Chem. Commun., 2024, 60, 9570 DOI: 10.1039/D4CC02850C
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