Photocatalytic redox-neutral α-C(sp3)–H pyridination of glycine derivatives and N-arylamines with cyanopyridines

Abstract

A photo-induced α-C(sp³)–H decyanative pyridination of N-arylglycine derivatives with cyanopyridines was developed. This reaction was performed under organic photocatalytic and redox-neutral conditions via a radical–radical cross-coupling process. Besides, the protocol was also suitable for the C(sp³)–H pyridination of N-aryl tetrahydroisoquinolines as well as benzylamines.