Ligand-free 99mTc-polyurea dendrimer complexes: nanoradiotheranostics targeting ovarian cancer

Adriana Cruz; Rita F. Pires; Paula Raposinho; Célia Fernandes; António Paulo; Vasco D.B. Bonifácio

doi:10.1039/D4CC00892H

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Ligand-free ^99mTc-polyurea dendrimer complexes: nanoradiotheranostics targeting ovarian cancer†

Adriana Cruz,^a Rita F. Pires,

‡^a Paula Raposinho,

^b Célia Fernandes,^b António Paulo*^bc and Vasco D.B. Bonifácio

*^ad

Author affiliations

* Corresponding authors

^a iBB-Institute for Bioengineering and Biosciences and i4HB-Institute for Health and Bioeconomy, Instituto Superior Técnico, Av. Rovisco Pais, 1049-001 Lisboa, Portugal
E-mail: vasco.bonifacio@tecnico.ulisboa.pt

^b Centro de Ciências e Tecnologias Nucleares, Instituto Superior Técnico, Universidade de Lisboa, Estrada Nacional 10, 2695-066 Bobadela LRS, Portugal
E-mail: apaulo@ctn.tecnico.ulisboa.pt

^c Departamento de Engenharia e Ciências Nucleares, Instituto Superior Técnico, Universidade de Lisboa, 1749-016 Lisboa, Portugal

^d Bioengineering Department, Instituto Superior Técnico, Av. Rovisco Pais, 1049-001 Lisboa, Portugal

Abstract

A folic acid-targeted polyurea (PURE) dendrimer was easily radiolabelled with Technetium-99m (^99mTc-PURE_G4-FA₂) avoiding the use of additional ligands and bioconjugation chemistry. This straightforward strategy is enabled in PURE dendrimers due to their favourable surface terminal groups configuration, showing coordination capabilities and turning these biodendrimers into attractive platforms for nanoradiotheranostics.

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Article information

DOI: https://doi.org/10.1039/D4CC00892H
Article type: Communication
Submitted: 24 Feb 2024
Accepted: 13 May 2024
First published: 13 May 2024

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Chem. Commun., 2024,60, 7874-7877

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Ligand-free ^99mTc-polyurea dendrimer complexes: nanoradiotheranostics targeting ovarian cancer

A. Cruz, R. F. Pires, P. Raposinho, C. Fernandes, A. Paulo and V. D.B. Bonifácio, Chem. Commun., 2024, 60, 7874 DOI: 10.1039/D4CC00892H

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Chemical Communications