Regulating the release of Mg-MOF from degradable bone cement by coating Mg-MOF with oxidized dextran/gelatin

Abstract

Degradable bone cement is widely used in the repair and treatment of bone defects due to its good plasticity and degradability and is also a good matrix for loading functional reagents or drugs. However, the release profile of drugs in bone cement will directly determine the performance of the bone cement. Coating drugs with natural polymer-based hydrogels is a common method of sustained drug release. Therefore, the magnesium gallate metal organic framework (Mg-MOF) with antibacterial properties is coated with oxidized dextran/gelatin (OD/Gel) and doped into the composite cement composed of calcium sulfate, calcium citrate and dicalcium phosphate anhydrous. The doping of OD/Gel@Mg-MOF has little effect on the microstructure and curing properties of the composite cement, but the mechanical strength of the cement increases from 27.20 MPa to 32.12 MPa. The controlled release of Mg-MOF can be sustainable for over 10 days, and OD/Gel@Mg-MOF bone cements exhibit excellent antibacterial properties against Staphylococcus aureus and Escherichia coli. Simultaneously, the composite bone cement can promote cell proliferation and osteogenic differentiation, alkaline phosphatase activity and calcium nodule deposition.