Copper-catalyzed oxidative direct C3-cyanoarylation of quinoxalin-2(1H)-ones via denitrogenative ring-opening of 3-aminoindazoles

Abstract

A convenient and efficient copper-catalyzed oxidative arylation of quinoxalin-2(1H)-ones with 3-aminoindazoles is developed for the synthesis of cyanoarylated quinoxalin-2(1H)-ones. Notably, 3-aminoindazoles are employed as efficient arylating agents via the cleavage of two C–N bonds. This oxidative arylation of quinoxalin-2(1H)-ones involves a radical process and undergoes a sequence of 3-aminoindazole oxidation, two C–N bond cleavage, and cyanoaryl radical addition.