Issue 13, 2023

Electrochemical oxidation-induced benzylic C(sp3)–H functionalization towards the atom-economic synthesis of oxazole heterocycles

Abstract

A unique electrochemical four-component reaction of terminal alkynes, (thio)xanthenes, nitriles, and water has been established in the absence of any catalyst or external oxidant. This electrochemical reaction features high atom economy and mild conditions, affording oxazole derivatives in moderate to good yields.

Graphical abstract: Electrochemical oxidation-induced benzylic C(sp3)–H functionalization towards the atom-economic synthesis of oxazole heterocycles

Supplementary files

Article information

Article type
Paper
Submitted
15 Dec 2022
Accepted
23 May 2023
First published
24 May 2023

Green Chem., 2023,25, 5128-5133

Electrochemical oxidation-induced benzylic C(sp3)–H functionalization towards the atom-economic synthesis of oxazole heterocycles

N. Yang, A. Li, H. Gao, L. Liao, Y. Yang, P. Wang and H. Li, Green Chem., 2023, 25, 5128 DOI: 10.1039/D2GC04782A

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