Issue 43, 2023

Inducing and monitoring mitochondrial pH changes with an iridium(iii) complex via two-photon lifetime imaging

Abstract

Real-time monitoring of mitochondrial dynamic changes plays a key role in the development of mitochondria-targeted anticancer theranostic agents. In this work, a pH-responsive and mitochondria-targeted cyclometalated iridium(III) complex MitoIr-NH has been explored as a novel anticancer agent. MitoIr-NH displayed pH-responsive phosphorescence intensity and lifetime, accumulated in mitochondria, showed higher antiproliferative activity and induced a series of mitochondria-related events. Moreover, MitoIr-NH could simultaneously induce mitophagy and quantitatively monitor mitochondrial pH changes through two-photon phosphorescence lifetime imaging microscopy (TPPLIM) in a real-time manner.

Graphical abstract: Inducing and monitoring mitochondrial pH changes with an iridium(iii) complex via two-photon lifetime imaging

Supplementary files

Article information

Article type
Paper
Submitted
09 Aug 2023
Accepted
02 Oct 2023
First published
05 Oct 2023

Dalton Trans., 2023,52, 15859-15865

Inducing and monitoring mitochondrial pH changes with an iridium(III) complex via two-photon lifetime imaging

M. Hu, X. Zhou, T. Xiao, L. Hao and Y. Li, Dalton Trans., 2023, 52, 15859 DOI: 10.1039/D3DT02541A

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