Issue 5, 2023

Fluorescent phenothiazine-fused boron complexes for ratiometric hypochlorite imaging

Abstract

Fluorescent hypochlorite probes with ratiometric imaging ability are highly desirable for imaging hypochlorite in biological systems. However, it is still challenging to develop new scaffolds for these probes. In this study, we demonstrate that phenothiazine-fused boron complexes are promising scaffolds for the design of ratiometric fluorescent hypochlorite probes. The synthesized complexes based on the scaffold show ultrafast and ratiometric absorption/fluorescence changes for hypochlorite. We also developed an endoplasmic reticulum-targeting probe and demonstrated that it has excellent real-time imaging ability for both endogenous and exogenous hypochlorite in the endoplasmic reticulum of living cells.

Graphical abstract: Fluorescent phenothiazine-fused boron complexes for ratiometric hypochlorite imaging

Supplementary files

Article information

Article type
Paper
Submitted
27 Nov 2022
Accepted
01 Jan 2023
First published
02 Jan 2023

Dalton Trans., 2023,52, 1393-1398

Fluorescent phenothiazine-fused boron complexes for ratiometric hypochlorite imaging

H. Wang, C. Zhang, Z. Jiang, L. Xu and Z. Liu, Dalton Trans., 2023, 52, 1393 DOI: 10.1039/D2DT03824B

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