Despite their popularity as enantioselective catalysts, the range of applications for Rieske dioxygenases has remained limited by their substrate scopes and selectivity. Herein, we report the development of dioxygenase variants with expanded substrate scopes through rational enzyme engineering. These catalysts have enabled the production of novel and valuable chiral metabolites.
E. A. Osifalujo, B. N. Rutkowski, L. R. Satterwhite, P. C. Betts, A. K. Nkosi and J. T. Froese, Catal. Sci. Technol., 2023, 13, 3784 DOI: 10.1039/D3CY00262D
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