Issue 99, 2023
From the journal:

Chemical Communications

Dual-responsive probe and DNA interstrand crosslink precursor target the unique redox status of cancer cells†

Dehao Yu,‡a   Luo Wang,‡a   Jingao Li,a   Xuanwei Zeng,a   Yuanyuan Jia,a   Junyu Tian,a   Anahit Campbell,b   Huabing Sun ORCID logo *a  and  Heli Fan ORCID logo *a  

* Corresponding authors

a The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, P. R. China
E-mail: sunhuabing@tmu.edu.cn, helifan@tmu.edu.cn

b Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, USA

Abstract

Elevated GSH and H2O2 in cancer cells is sometimes doubted due to their contrary reactivities. Here, we construct a dual-responsive fluorescent probe to confirm the conclusion, and employ this to exploit a redox-inducible DNA interstrand crosslink (ICL) precursor. It crosslinks DNA upon activation by GSH and H2O2, affording an alternative dual-responsive strategy.

Graphical abstract: Dual-responsive probe and DNA interstrand crosslink precursor target the unique redox status of cancer cells

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Article information

DOI
https://doi.org/10.1039/D3CC05175G
Article type
Communication
Submitted
20 Oct 2023
Accepted
06 Nov 2023
First published
07 Nov 2023

Chem. Commun., 2023,59, 14705-14708

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Dual-responsive probe and DNA interstrand crosslink precursor target the unique redox status of cancer cells

D. Yu, L. Wang, J. Li, X. Zeng, Y. Jia, J. Tian, A. Campbell, H. Sun and H. Fan, Chem. Commun., 2023, 59, 14705 DOI: 10.1039/D3CC05175G

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