Issue 90, 2023
From the journal:

Chemical Communications

Convergent synthesis of proteins using peptide-aminothiazoline†

Ryo Okamoto, ORCID logo *ab   Hiroyuki Shibata,a   Takahiro Yatsuzuka,a   Takuya Hanao,a   Yuta Maki, ORCID logo ab   Kazuya Kabayama,ab   Ayane Miura,a   Koichi Fukase ORCID logo abc  and  Yasuhiro Kajihara ORCID logo *ab  

* Corresponding authors

a Department of Chemistry, Graduate School of Science, Osaka University, 1-1, Machikaneyama, Toyonaka, Osaka 560-0043, Japan

b Forefront Research Center, Osaka University, 1-1, Machikaneyama, Toyonaka, Osaka 560-0043, Japan

c Center for Advanced Modalities and DDS, Osaka University, 1-1, Yamadaoka, Suita, Osaka 565-0871, Japan

Abstract

Sequential peptide coupling plays a central role in chemical protein synthesis. This paper describes a new peptide derivative, peptide-aminothiazoline (At), whereof the C-terminus is functionalized with 2-aminothiazoline. Peptide-At streamlined the sequential peptide ligation in a one-pot manner and demonstrated the convergent synthesis of a circular protein and homogeneous glycoproteins.

Graphical abstract: Convergent synthesis of proteins using peptide-aminothiazoline

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Article information

DOI
https://doi.org/10.1039/D3CC04387H
Article type
Communication
Submitted
05 Sep 2023
Accepted
17 Oct 2023
First published
27 Oct 2023

Chem. Commun., 2023,59, 13510-13513

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Convergent synthesis of proteins using peptide-aminothiazoline

R. Okamoto, H. Shibata, T. Yatsuzuka, T. Hanao, Y. Maki, K. Kabayama, A. Miura, K. Fukase and Y. Kajihara, Chem. Commun., 2023, 59, 13510 DOI: 10.1039/D3CC04387H

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