Issue 21, 2023
From the journal:

Chemical Communications

A dual-amplified ROS-responsive nanosystem with self-accelerating drug release for synergistic chemotherapy†

Jun Li,‡a   Qingyu Zong,‡b   Zhongyi Zhaoc  and  Youyong Yuan ORCID logo *bde  

* Corresponding authors

a School of Biology and Biological Engineering, South China University of Technology, Guangzhou, P. R. China
E-mail: yuanyy@scut.edu.cn

b National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, P. R. China

c Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou, P. R. China

d School of Biomedical Sciences and Engineering, Guangzhou International Campus, South China University of Technology, Guangzhou, P. R. China

e Guangdong Provincial Key Laboratory of Biomedical Engineering, South China University of Technology, Guangzhou, P. R. China

Abstract

In this work, we have developed a tumor-specific self-accelerating prodrug activation nanosystem consisting of self-amplifying degradable polyprodrug PEG-TA-CA-DOX and encapsulated fluorescent prodrug BCyNH2, equipped with a reactive oxygen species dual-cycle amplification effect. Furthermore, activated CyNH2 is a therapeutic agent with potential to synergistically improve chemotherapy.

Graphical abstract: A dual-amplified ROS-responsive nanosystem with self-accelerating drug release for synergistic chemotherapy

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Article information

DOI
https://doi.org/10.1039/D3CC00052D
Article type
Communication
Submitted
04 Jan 2023
Accepted
09 Feb 2023
First published
22 Feb 2023

Chem. Commun., 2023,59, 3142-3145

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A dual-amplified ROS-responsive nanosystem with self-accelerating drug release for synergistic chemotherapy

J. Li, Q. Zong, Z. Zhao and Y. Yuan, Chem. Commun., 2023, 59, 3142 DOI: 10.1039/D3CC00052D

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