Issue 29, 2022
From the journal:

Organic & Biomolecular Chemistry

Photocatalytic difluoromethylarylation of unactivated alkenes via a (hetero)aryl neophyl-like radical migration†

Ziran Lei,‡a   Siqi Wei,a   Liejin Zhou, ORCID logo *a   Zuxiao Zhang, ORCID logo *ab   Simon E. Lopezb  and  William R. Dolbier, Jr. ORCID logo *b  

* Corresponding authors

a Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Department of Chemistry, Zhejiang Normal University, 688 Yingbin Road, Jinhua 321004, P. R. China
E-mail: ljzhou@zjnu.cn

b Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA
E-mail: wrd@chem.ufl.edu

Abstract

Photoredox-catalyzed addition of the difluoromethylradical to unactivated alkenes has been found to trigger neophyl-like aryl and heteroaryl migrations which allowed the construction of a diverse series of difluoromethyl ketones. The reaction featured mild reaction conditions and broad substrate scope.

Graphical abstract: Photocatalytic difluoromethylarylation of unactivated alkenes via a (hetero)aryl neophyl-like radical migration

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Article information

DOI
https://doi.org/10.1039/D2OB00813K
Article type
Communication
Submitted
28 Apr 2022
Accepted
04 Jul 2022
First published
05 Jul 2022

Org. Biomol. Chem., 2022,20, 5712-5715

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Photocatalytic difluoromethylarylation of unactivated alkenes via a (hetero)aryl neophyl-like radical migration

Z. Lei, S. Wei, L. Zhou, Z. Zhang, S. E. Lopez and W. R. Dolbier, Org. Biomol. Chem., 2022, 20, 5712 DOI: 10.1039/D2OB00813K

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