Direct C–H functionalization of tetrahydro-γ-carbolines at the α-position

Yahui Zhang; Yi Chen; Mei Guo; Ge Sun; Rongbin Que; Ranran Cui; Yu Gao; Haijun Chen

doi:10.1039/D2NJ00928E

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Direct C–H functionalization of tetrahydro-γ-carbolines at the α-position†

Yahui Zhang,‡^a Yi Chen,‡^a Mei Guo,‡^a Ge Sun,^a Rongbin Que,^a Ranran Cui,^a Yu Gao

*^a and Haijun Chen

*^a

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* Corresponding authors

^a Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, FuZhou University, Fuzhou, Fujian 350116, China
E-mail: chenhaij@gmail.com, hellogaoyu@126.com

Abstract

The direct C–H functionalization of tetrahydro-γ-carbolines (THγCs) at the α-position has been presented. This mild and simple strategy allows coupling of THγCs with various anilines and indoles with satisfactory to excellent yields. This two-step/one-pot method could be applied to synthesize complex compounds and is suitable for the C–H functionalization of similar biologically active structures.

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DOI: https://doi.org/10.1039/D2NJ00928E
Article type: Communication
Submitted: 23 Feb 2022
Accepted: 24 Apr 2022
First published: 25 Apr 2022

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New J. Chem., 2022,46, 9511-9514

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Direct C–H functionalization of tetrahydro-γ-carbolines at the α-position

Y. Zhang, Y. Chen, M. Guo, G. Sun, R. Que, R. Cui, Y. Gao and H. Chen, New J. Chem., 2022, 46, 9511 DOI: 10.1039/D2NJ00928E

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New Journal of Chemistry

Direct C–H functionalization of tetrahydro-γ-carbolines at the α-position†

Abstract

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Direct C–H functionalization of tetrahydro-γ-carbolines at the α-position

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