Issue 15, 2022

Synergistic TME-manipulation effects of a molybdenum-based polyoxometalate enhance the PTT effects on cancer cells

Abstract

The intrinsic features of tumors often give rise to unsatisfactory outcomes of photothermal treatment (PTT). Remarkably, the tumor microenvironment (TME) with abundant antioxidants, elevated hydrogen peroxide (H2O2), and low pH has proven to be a tremendous obstacle for tumor treatment. Therefore, developing an effective photosensitizer that can respond to both NIR radiation and TME is imperative but remains a challenge. Here, we explore a molybdenum-based polyoxometalate (Na15[MoVI126-MoV28O462H14(H2O)70]ยท400H2O, [Mo154]) as a photosensitizer for TME-manipulated PTT enhancement because of the following features. Firstly, the 808 nm absorption of [Mo154] can be increased via pH-induced aggregation; secondly, due to the unique multi-electron property, [Mo154] can deplete cysteine and reactive oxygen species (ROS) via redox reactions; thirdly, reduced [Mo154] ([rMo154]) can further improve the 808 nm absorption by promoting the transition from Mo(VI) to Mo(V). Consequently, [Mo154] can overcome several obstacles in TME and thus improve the PTT efficiency by synergizing the effects of pH-induced aggregation, cysteine reduction and depletion, and free-radical scavenging. In addition to providing a promising photosensitizer for PTT, this finding extends the application of molybdenum-based polyoxometalates in the biomedical field.

Graphical abstract: Synergistic TME-manipulation effects of a molybdenum-based polyoxometalate enhance the PTT effects on cancer cells

Supplementary files

Article information

Article type
Paper
Submitted
18 Jan 2022
Accepted
28 Feb 2022
First published
01 Mar 2022

New J. Chem., 2022,46, 6932-6939

Synergistic TME-manipulation effects of a molybdenum-based polyoxometalate enhance the PTT effects on cancer cells

G. Chen, Y. Wang, X. Kong, H. Li, B. Li, X. Yu, L. Wu and Y. Wu, New J. Chem., 2022, 46, 6932 DOI: 10.1039/D2NJ00278G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements