Issue 76, 2022

A pH-activated fluorescent probe via transformation of azo and hydrazone forms for lysosomal pH imaging

Abstract

We developed a fluorescent probe Sth-NH by introducing a 6-hydroxypyridone skeleton. The presence of an active proton enables the probe to transform from a deprotonated azo form to a hydrazone form in a strongly acidic environment to realize fluorescence light-up behavior, thus monitoring the lower lysosomal pH of cancer cells and distinguishing them from normal cells.

Graphical abstract: A pH-activated fluorescent probe via transformation of azo and hydrazone forms for lysosomal pH imaging

Supplementary files

Article information

Article type
Communication
Submitted
18 Jul 2022
Accepted
19 Aug 2022
First published
22 Aug 2022

Chem. Commun., 2022,58, 10635-10638

A pH-activated fluorescent probe via transformation of azo and hydrazone forms for lysosomal pH imaging

X. Zhao, C. Yan, W. Qiu, T. Yu, W. Wang and W. Zhu, Chem. Commun., 2022, 58, 10635 DOI: 10.1039/D2CC03999K

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