An azido pyridoxal derivative (PLAA) was developed as a protein azidolation reagent, with selectivity towards N-terminal glycine. Successful PLAA modification was achieved with small peptides, natural proteins and lab-expressed proteins under mild conditions, offering a unique method for post-synthesis site-specific azidolation of a peptide or protein.
B. Wang, X. Li, Y. Wang, X. Mao and X. Wang, Chem. Commun., 2022, 58, 7408 DOI: 10.1039/D2CC03051A
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