Issue 64, 2022
From the journal:

Chemical Communications

Electrosynthesis of (hetero)aryl nitriles from α-imino-oxy acids via oxidative decarboxylation/N–O cleavage†

Hui-Shan Lin,a   Shu-Jun Chena  and  Jing-Mei Huang ORCID logo *a  

* Corresponding authors

a Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, Guangdong 510640, China
E-mail: chehjm@scut.edu.cn

Abstract

A new method for the synthesis of (hetero)aryl nitriles via iminyl radicals has been developed through the electrochemical oxidative decarboxylation of α-imino-oxy acids. This protocol provides an efficient approach to nitriles with a broad range of functional-group tolerance under ambient conditions and can be applied for one-pot gram-scale synthesis.

Graphical abstract: Electrosynthesis of (hetero)aryl nitriles from α-imino-oxy acids via oxidative decarboxylation/N–O cleavage

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Article information

DOI
https://doi.org/10.1039/D2CC02986C
Article type
Communication
Submitted
26 May 2022
Accepted
11 Jul 2022
First published
12 Jul 2022

Chem. Commun., 2022,58, 8974-8977

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Electrosynthesis of (hetero)aryl nitriles from α-imino-oxy acids via oxidative decarboxylation/N–O cleavage

H. Lin, S. Chen and J. Huang, Chem. Commun., 2022, 58, 8974 DOI: 10.1039/D2CC02986C

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