Issue 44, 2022
From the journal:

Chemical Communications

Mitochondria-targeted fluorescent probe for visualization of exogenous and endogenous methylglyoxal in living cells†

Zhiming Wang,a   Yaye Bian,a   Chang Liu,*a   Song He,a   Liancheng Zhaob  and  Xianshun Zeng ORCID logo *ab  

* Corresponding authors

a Tianjin Key Laboratory for Photoelectric Materials and Devices, and Key Laboratory of Display Materials & Photoelectric Devices, Ministry of Education, School of Materials Science & Engineering, Tianjin University of Technology, Tianjin, China

b School of Materials Science and Engineering, Harbin Institute of Technology, Harbin, China

Abstract

An activatable mitochondria-targeted fluorescent probe Hcy-OPD was synthesized for the detection of methylglyoxal (MGO). For the introduction of a preorganized isopropylamino group on the aromatic o-diamine framework to regulate the hindrance effect, Hcy-OPD showed high selectivity and sensitivity (0.22 μM) for monitoring MGO. The probe can be applied successfully in the imaging of exogenous and endogenous MGO in living cells.

Graphical abstract: Mitochondria-targeted fluorescent probe for visualization of exogenous and endogenous methylglyoxal in living cells

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Article information

DOI
https://doi.org/10.1039/D2CC01503J
Article type
Communication
Submitted
16 Mar 2022
Accepted
04 May 2022
First published
09 May 2022

Chem. Commun., 2022,58, 6453-6456

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Mitochondria-targeted fluorescent probe for visualization of exogenous and endogenous methylglyoxal in living cells

Z. Wang, Y. Bian, C. Liu, S. He, L. Zhao and X. Zeng, Chem. Commun., 2022, 58, 6453 DOI: 10.1039/D2CC01503J

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