In situ fluorescence imaging reveals that mitochondrial H2O2 mediates lysosomal dysfunction in depression

Xin Wang; Qi Ding; Ying Tian; Wei Wu; Feida Che; Ping Li; Wen Zhang; Wei Zhang; Bo Tang

doi:10.1039/D2CC00431C

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In situ fluorescence imaging reveals that mitochondrial H₂O₂ mediates lysosomal dysfunction in depression†

Xin Wang,‡^a Qi Ding,‡^a Ying Tian,^a Wei Wu,*^b Feida Che,^a Ping Li,

*^a Wen Zhang,

^a Wei Zhang^a and Bo Tang

*^a

Author affiliations

* Corresponding authors

^a College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Institutes of Biomedical Sciences, Shandong Normal University, Jinan 250014, P. R. China
E-mail: lip@sdnu.edu.cn, tangb@sdnu.edu.cn

^b Department of Neurology, Qi-Lu Hospital of Shandong University and Brain Science Research Institute, Shandong University Jinan, Shandong 250012, P. R. China
E-mail: drwuwei@126.com

Abstract

We constructed two fluorescent probes for monitoring H₂O₂ in the mitochondria and lysosomes. Fluorescence imaging reveals that mitochondrial H₂O₂ mediates reduced GCase activity in lysosomes in the brains of mice with depression. This work provides a powerful tool for understanding the pathogenesis of depression.

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Article information

DOI: https://doi.org/10.1039/D2CC00431C
Article type: Communication
Submitted: 22 Jan 2022
Accepted: 23 Mar 2022
First published: 02 Apr 2022

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Chem. Commun., 2022,58, 6320-6323

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In situ fluorescence imaging reveals that mitochondrial H₂O₂ mediates lysosomal dysfunction in depression

X. Wang, Q. Ding, Y. Tian, W. Wu, F. Che, P. Li, W. Zhang, W. Zhang and B. Tang, Chem. Commun., 2022, 58, 6320 DOI: 10.1039/D2CC00431C

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