Issue 24, 2022

Ligand-enabled palladium-catalyzed hydroesterification of vinyl arenes with high linear selectivity to access 3-arylpropanoate esters

Abstract

Palladium-catalyzed linear-selective hydroesterification of vinyl arenes with alcohols enabled by diphosphine ligands derived from bis[2-(diphenylphosphino)ethyl]amides has been developed. A variety of 3-arylpropanoate esters were obtained in high yields and regioselectivity. The robustness of this methodology was further demonstrated by the efficient gram-scale synthesis of the ethyl 3-phenylpropanoate as a precursor to hydrocinnamic acid.

Graphical abstract: Ligand-enabled palladium-catalyzed hydroesterification of vinyl arenes with high linear selectivity to access 3-arylpropanoate esters

Supplementary files

Article information

Article type
Communication
Submitted
13 Jan 2022
Accepted
23 Feb 2022
First published
24 Feb 2022

Chem. Commun., 2022,58, 3921-3924

Ligand-enabled palladium-catalyzed hydroesterification of vinyl arenes with high linear selectivity to access 3-arylpropanoate esters

Z. Deng, S. Han, M. Ke, Y. Ning and F. Chen, Chem. Commun., 2022, 58, 3921 DOI: 10.1039/D2CC00228K

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