Burnt bridge ratchet motor force scales linearly with polyvalency: a computational study

Abstract

Nano- and micro-scale burnt bridge ratchet motors, which translocate via “guide” molecules that bind to and degrade a field of “fuel” molecules, have recently emerged in several biological and engineering contexts. The capacity of these motors to generate mechanical forces remains an open question. Here, chemomechanical modeling suggests that BBR force scales linearly with the steady-state number of guide-fuel bonds.