Issue 12, 2021

Chiral lithium amide mediated desymmetrization of 3-substituted cyclobutanone

Abstract

We report here a practical strategy to access enantioenriched cyclobutenes via chiral lithium amide mediated deprotonation of 3-substituted cyclobutanones. Furthermore, this strategy has been applied to access protoilludane analogues via a sequential Negishi coupling of enol phosphates and Diels–Alder reaction.

Graphical abstract: Chiral lithium amide mediated desymmetrization of 3-substituted cyclobutanone

Supplementary files

Article information

Article type
Research Article
Submitted
05 Jan 2021
Accepted
30 Mar 2021
First published
13 Apr 2021

Org. Chem. Front., 2021,8, 2977-2980

Chiral lithium amide mediated desymmetrization of 3-substituted cyclobutanone

C. Zhong, S. Wang and P. Lu, Org. Chem. Front., 2021, 8, 2977 DOI: 10.1039/D1QO00015B

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