Rh(III)-Catalyzed sulfonylamination of α-indolyl alcohols via Csp2–Csp3 bond cleavage

Xinwei Hu; Zheng Tan; Zhipeng Liu; Fengjuan Chen; Huanfeng Jiang; Wei Zeng

doi:10.1039/D0QO01426E

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Rh(iii)-Catalyzed sulfonylamination of α-indolyl alcohols via Csp²–Csp³ bond cleavage†

Xinwei Hu,^a Zheng Tan,^a Zhipeng Liu,^a Fengjuan Chen,^a Huanfeng Jiang

^a and Wei Zeng

*^a

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* Corresponding authors

^a Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, China
E-mail: zengwei@scut.edu.cn

Abstract

A Rh(III)-catalyzed beta-carbon amination of α-aryl alcohols with sulfonyl azides has been developed. This transformation features unstrained Csp²–Csp³ σ bond amination via C–C σ bond cleavage, and provides a direct approach to complex 2-aminoindoles.

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Article information

DOI: https://doi.org/10.1039/D0QO01426E
Article type: Research Article
Submitted: 16 Nov 2020
Accepted: 29 Dec 2020
First published: 30 Dec 2020

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Org. Chem. Front., 2021,8, 983-987

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Rh(III)-Catalyzed sulfonylamination of α-indolyl alcohols via Csp²–Csp³ bond cleavage

X. Hu, Z. Tan, Z. Liu, F. Chen, H. Jiang and W. Zeng, Org. Chem. Front., 2021, 8, 983 DOI: 10.1039/D0QO01426E

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