Issue 20, 2021

Hybrid system {W6I8}-cluster/dsDNA as an agent for targeted X-ray induced photodynamic therapy of cancer stem cells

Abstract

Metastasis is one of the leading causes of the recurrence and high mortality of cancer. According to a recent hierarchical model of tumour formation, cancer stem cells (CSCs) are responsible for the occurrence of metastases and cancer relapse. Unfortunately, these cells are believed to have high resistance to conventional treatments. The development of therapies focused on the targeted elimination of cancer stem cells is now viewed as a new and advantageous approach to cancer treatment. Here we present a new material – a hybrid of double-stranded DNA (dsDNA) and hexatungsten iodide octahedral cluster {W6I8}4+ – as an effective agent for the targeted X-ray induced photodynamic therapy (X-PDT) of cancer stem cells. Specifically, our approach was to employ an intrinsic property of CSCs to selectively internalise dsDNA molecules to drag {W6I8}, scintillating and photosensitising moieties, directly into CSCs. The hybrid material has high stability in aqueous media, low cytotoxicity in the absence of irradiation, and significant selective cellular uptake by CSCs. X-Ray irradiation of CSCs incubated with the material resulted in an extremely low growth rate of the solid tumour in model CBA mice.

Graphical abstract: Hybrid system {W6I8}-cluster/dsDNA as an agent for targeted X-ray induced photodynamic therapy of cancer stem cells

Supplementary files

Article information

Article type
Research Article
Submitted
30 Jun 2021
Accepted
10 Aug 2021
First published
11 Aug 2021

Mater. Chem. Front., 2021,5, 7499-7507

Hybrid system {W6I8}-cluster/dsDNA as an agent for targeted X-ray induced photodynamic therapy of cancer stem cells

T. N. Pozmogova, N. A. Sitnikova, E. V. Pronina, S. M. Miroshnichenko, A. O. Kushnarenko, A. O. Solovieva, S. S. Bogachev, G. D. Vavilov, O. A. Efremova, Y. A. Vorotnikov and M. A. Shestopalov, Mater. Chem. Front., 2021, 5, 7499 DOI: 10.1039/D1QM00956G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements