Issue 31, 2021

Y(OTf)3-catalyzed phosphorylation of 2H-chromene hemiacetals with P(O)–H compounds to 2-phosphorylated 2H-chromenes

Abstract

A facile synthesis of 2-phosphorylated 2H-chromenes has been accomplished herein via a Y(OTf)3-catalyzed dehydrative coupling of 2H-chromene hemiacetals with P(O)–H compounds. This protocol features low catalyst loading, mild reaction conditions, broad substrate scope and easy elaboration of the products.

Graphical abstract: Y(OTf)3-catalyzed phosphorylation of 2H-chromene hemiacetals with P(O)–H compounds to 2-phosphorylated 2H-chromenes

Supplementary files

Article information

Article type
Paper
Submitted
24 Jun 2021
Accepted
19 Jul 2021
First published
19 Jul 2021

Org. Biomol. Chem., 2021,19, 6812-6816

Y(OTf)3-catalyzed phosphorylation of 2H-chromene hemiacetals with P(O)–H compounds to 2-phosphorylated 2H-chromenes

S. Zheng, Y. Zou, Z. Wen, J. Lin, L. Gu and L. Chen, Org. Biomol. Chem., 2021, 19, 6812 DOI: 10.1039/D1OB01221E

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