Issue 86, 2021

Organocatalytic cascade reactions for multi-functionalized chiral cyclic ethers through vinylidene ortho-quinone methides

Abstract

An organocatalytic approach to installing various alcohols into the carbonyl of α,β-unsaturated ketones mediated by VQM intermediates was achieved, followed by dearomatization to provide the stereo-defined cyclic ethers via a cascade process. Along with the transformations, this strategy affords efficient access to the underexplored chiral cyclic ether chemospace.

Graphical abstract: Organocatalytic cascade reactions for multi-functionalized chiral cyclic ethers through vinylidene ortho-quinone methides

Supplementary files

Article information

Article type
Communication
Submitted
22 Sep 2021
Accepted
04 Oct 2021
First published
05 Oct 2021

Chem. Commun., 2021,57, 11334-11337

Organocatalytic cascade reactions for multi-functionalized chiral cyclic ethers through vinylidene ortho-quinone methides

S. Jia, Y. Chang, Y. Tian, H. Mao, W. Qin, P. Wang and H. Yan, Chem. Commun., 2021, 57, 11334 DOI: 10.1039/D1CC05340J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements