Issue 31, 2021

Programming DNA cascade circuits on live cell membranes for accurate cancer cell recognition and gene silencing

Abstract

A dual-aptamer based AND logic cascade circuit is activated on cell membranes in response to the receptor–aptamer binding, affording enhanced specificity for cell subtype recognition and gene silencing.

Graphical abstract: Programming DNA cascade circuits on live cell membranes for accurate cancer cell recognition and gene silencing

Supplementary files

Article information

Article type
Communication
Submitted
27 Jan 2021
Accepted
09 Mar 2021
First published
10 Mar 2021

Chem. Commun., 2021,57, 3816-3819

Programming DNA cascade circuits on live cell membranes for accurate cancer cell recognition and gene silencing

X. Wang, L. Liu, H. Wu, Z. Wu, L. Tang and J. Jiang, Chem. Commun., 2021, 57, 3816 DOI: 10.1039/D1CC00481F

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