Mitochondria selective trackers for long-term imaging based on readily accessible neutral BODIPYs

Ágata Ramos-Torres; Edurne Avellanal-Zaballa; Fernando García-Garrido; Ana B. Fernández-Martínez; Alejandro Prieto-Castañeda; Antonia R. Agarrabeitia; Jorge Bañuelos; Inmaculada García-Moreno; Francisco-Javier Lucio-Cazaña; María J. Ortiz

doi:10.1039/D1CC00451D

Mitochondria selective trackers for long-term imaging based on readily accessible neutral BODIPYs†

Ágata Ramos-Torres,^a Edurne Avellanal-Zaballa,^b Fernando García-Garrido,^c Ana B. Fernández-Martínez,^d Alejandro Prieto-Castañeda,

^c Antonia R. Agarrabeitia,^c Jorge Bañuelos,

^b Inmaculada García-Moreno,^e Francisco-Javier Lucio-Cazaña

^a and María J. Ortiz

*^c

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* Corresponding authors

^a Universidad de Alcalá, Departamento de Biología de Sistemas, Facultad de Medicina y Ciencias de la Salud, Campus Universitario, Crtra A2, Km. 33,600 28805, Alcalá de Henares, Madrid, Spain

^b Departamento de Química-Física, Universidad del País Vasco (UPV/EHU), Apartado 644, Bilbao 48080, Spain

^c Departamento de Química Orgánica, Facultad de CC. Químicas, Universidad Complutense de Madrid, Ciudad Universitaria s/n, Madrid 28040, Spain
E-mail: mjortiz@quim.ucm.es

^d Departamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, Darwin 2, Madrid 28049, Spain

^e Departamento de Sistemas de Baja Dimensionalidad, Superficies y Materia Condensada, Instituto de Química-Física “Rocasolano”, CSIC, Serrano 119, Madrid 28006, Spain

Abstract

We report the design of a new model based on a small neutral 8-aryl-3-formylBODIPY and its suitability to develop privileged highly bright and photostable fluorescent probes for selective and, more importantly, covalent staining of mitochondria.

Chemical Communications

Mitochondria selective trackers for long-term imaging based on readily accessible neutral BODIPYs†

Abstract

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Mitochondria selective trackers for long-term imaging based on readily accessible neutral BODIPYs

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