Developing benign syntheses using ion pairs via solvent-free mechanochemistry

Abstract

Solvent-free mechanochemical conditions have been developed to investigate the significance of ion pairing and the use of weak bases for driving forward nucleophilic substitution reactions. This approach takes advantage of the lack of solvent shells to incorporate weaker and safer bases to drive reactions to completion through specific ion pairing pathways. The most efficient reactions contained larger and more polarizable cation and anion pairs.