We developed a superior class of light-activatable molecular beacons with photo-tethered loop regions. Two simple modifications and probe cyclisation prevent the molecular beacon from hybridising with the target RNA before light-activation. Full activity of the molecular beacon is elicited upon illumination with 365 nm light.
R. Klimek, M. Wang, V. R. McKenney, E. M. Schuman and A. Heckel, Chem. Commun., 2021, 57, 615 DOI: 10.1039/D0CC06704K
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