Issue 48, 2020
From the journal:

Chemical Communications

A fentanyl vaccine constructed upon opsonizing antibodies specific for the Galα1–3Gal epitope†

Jiaxing Wang, ORCID logo a   Beverly Ellis, ORCID logo a   Bin Zhou, ORCID logo a   Lisa M. Eubanks, ORCID logo a   Steven Blake ORCID logo a  and  Kim D. Janda ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Department of Immunology and Microbial Science, The Skaggs Institute for Chemical Biology, The Worm Institute for Research and Medicine (WIRM), The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
E-mail: kdjanda@scripps.edu

Abstract

A double conjugation strategy was implemented to produce an anti-fentanyl vaccine, which was predicated upon preformed-antibody-assisted antigen presentation. The new vaccine was found to reduce the psychoactive effects of fentanyl without the addition of the immunostimulant CpG oligodeoxynucleotide.

Graphical abstract: A fentanyl vaccine constructed upon opsonizing antibodies specific for the Galα1–3Gal epitope

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Article information

DOI
https://doi.org/10.1039/D0CC02107E
Article type
Communication
Submitted
22 Mar 2020
Accepted
03 May 2020
First published
04 May 2020

Chem. Commun., 2020,56, 6551-6554

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A fentanyl vaccine constructed upon opsonizing antibodies specific for the Galα1–3Gal epitope

J. Wang, B. Ellis, B. Zhou, L. M. Eubanks, S. Blake and K. D. Janda, Chem. Commun., 2020, 56, 6551 DOI: 10.1039/D0CC02107E

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