Chiral-at-metal rhodium(iii) complex catalyzed enantioselective synthesis of C2-substituted benzofuran derivatives

Abstract

A highly efficient enantioselective C2-nucleophilic functionalization of 3-aminobenzofurans with α,β-unsaturated carbonyl compounds has been realized under catalysis of chiral-at-metal rhodium(III) complexes, affording a large array of potentially bioactive C2-substituted benzofuran derivatives with high yields (76–99%) and enantioselectivities (up to 98% ee).