LAMP-generated H+ ions-induced dimer i-motif as signal transducer for ultrasensitive electrochemical detection of DNA

Xiaoyu Hua; Enfen Yang; Wenting Yang; Ruo Yuan; Wenju Xu

doi:10.1039/C9CC06738H

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LAMP-generated H⁺ ions-induced dimer i-motif as signal transducer for ultrasensitive electrochemical detection of DNA†

Xiaoyu Hua,^a Enfen Yang,^a Wenting Yang,^a Ruo Yuan

*^a and Wenju Xu

*^a

Author affiliations

* Corresponding authors

^a Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China
E-mail: xwju@swu.edu.cn, yuanruo@swu.edu.cn

Abstract

Herein, an ultrasensitive electrochemical biosensor is proposed for the quantification of the Flu A virus biomarker DNA (fDNA), and is based on loop-mediated isothermal amplification-generated hydrogen ions (LAMP-H⁺) which induce the formation of the dimer i-motif structure (DiMS) for signal transduction, coupled with exonuclease III (ExoIII)-assisted DNA walking for signal dual-amplification.

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Article information

DOI: https://doi.org/10.1039/C9CC06738H
Article type: Communication
Submitted: 30 Aug 2019
Accepted: 18 Sep 2019
First published: 19 Sep 2019

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Chem. Commun., 2019,55, 12463-12466

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LAMP-generated H⁺ ions-induced dimer i-motif as signal transducer for ultrasensitive electrochemical detection of DNA

X. Hua, E. Yang, W. Yang, R. Yuan and W. Xu, Chem. Commun., 2019, 55, 12463 DOI: 10.1039/C9CC06738H

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Chemical Communications