Highly sensitive and selective mercury sensor based on mismatched base pairing with dioxT

Ji Hoon Han; Shingo Hirashima; Soyoung Park; Hiroshi Sugiyama

doi:10.1039/C9CC05123F

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Highly sensitive and selective mercury sensor based on mismatched base pairing with ^dioxT†

Ji Hoon Han,^a Shingo Hirashima,^a Soyoung Park

*^a and Hiroshi Sugiyama

*^ab

Author affiliations

* Corresponding authors

^a Department of Chemistry, Graduate School of Science Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan
E-mail: oleesy@kuchem.kyoto-u.ac.jp, hs@kuchem.kyoto-u.ac.jp

^b Institute for Integrated Cell-Material Science (iCeMS) Kyoto University, Yoshida-ushinomiyacho Sakyo-ku, Kyoto 606-8501, Japan

Abstract

A highly selective and sensitive sensor for mercury was designed based on a new fluorescent nucleobase, ^dioxT. Its metal-sensing ability was investigated using mismatched ^dioxT-T and ^dioxT-C base pairing. The sensor exhibited a high sensitivity (quenching efficiency, 80%, 1 : 1 binding mode) and selectivity upon the addition of mercury ions.

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Article information

DOI: https://doi.org/10.1039/C9CC05123F
Article type: Communication
Submitted: 04 Jul 2019
Accepted: 26 Jul 2019
First published: 01 Aug 2019

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Chem. Commun., 2019,55, 10245-10248

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Highly sensitive and selective mercury sensor based on mismatched base pairing with ^dioxT

J. H. Han, S. Hirashima, S. Park and H. Sugiyama, Chem. Commun., 2019, 55, 10245 DOI: 10.1039/C9CC05123F

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Chemical Communications