Issue 33, 2019
From the journal:

Chemical Communications

A mitochondria targeting artesunate prodrug-loaded nanoparticle exerting anticancer activity via iron-mediated generation of the reactive oxygen species†

Zhigang Chen,ab   Xiaoxu Kang,bc   Yixin Wu,bc   Haihua Xiao,bd   Xuzi Cai,e   Shihou Sheng,*f   Xuefeng Wang*e  and  Shiguo Chen ORCID logo *a  

* Corresponding authors

a Nanshan District Key Lab for Biopolymers and Safety Evaluation, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, P. R. China
E-mail: csg@szu.edu.cn

b Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China

c College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, P. R. China

d University of Chinese Academy of Sciences, Beijing 100049, P. R. China

e Department of Obstetrics and Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, P. R. China
E-mail: douwangxuefeng@163.com

f Department of Gastrointestinal Surgery China-Japan Union Hospital of Jilin University, Changchun 130033, P. R. China
E-mail: shengfandayeren@126.com

Abstract

An artesunate anticancer prodrug with a long aliphatic chain N,N′-bis(dodecyl)-L-glutamic diamide was developed into nanoparticle via iron-mediated ROS generation.

Graphical abstract: A mitochondria targeting artesunate prodrug-loaded nanoparticle exerting anticancer activity via iron-mediated generation of the reactive oxygen species

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Article information

DOI
https://doi.org/10.1039/C9CC00531E
Article type
Communication
Submitted
21 Jan 2019
Accepted
20 Mar 2019
First published
20 Mar 2019

Chem. Commun., 2019,55, 4781-4784

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A mitochondria targeting artesunate prodrug-loaded nanoparticle exerting anticancer activity via iron-mediated generation of the reactive oxygen species

Z. Chen, X. Kang, Y. Wu, H. Xiao, X. Cai, S. Sheng, X. Wang and S. Chen, Chem. Commun., 2019, 55, 4781 DOI: 10.1039/C9CC00531E

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