A novel near-infrared fluorescent light-up probe for tumor imaging and drug-induced liver injury detection

Xiaodong Zeng; Ziyang Chen; Lin Tang; Han Yang; Nan Liu; Hui Zhou; Yang Li; Junzhu Wu; Zixin Deng; Yi Yu; Hai Deng; Xuechuan Hong; Yuling Xiao

doi:10.1039/C8CC10286D

A novel near-infrared fluorescent light-up probe for tumor imaging and drug-induced liver injury detection†

Xiaodong Zeng,

‡^a Ziyang Chen,‡^a Lin Tang,‡^a Han Yang,^a Nan Liu,^b Hui Zhou,

^a Yang Li,^a Junzhu Wu,^b Zixin Deng,^a Yi Yu,

^a Hai Deng,

*^c Xuechuan Hong

*^a and Yuling Xiao*^a

Author affiliations

* Corresponding authors

^a State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE), Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China
E-mail: xiaoyl@whu.edu.cn, xhy78@whu.edu.cn

^b Hubei Provincial Key Laboratory of Developmentally Originated Disease, Center for Experimental Basic Medical Education, Wuhan 430071, China

^c Department of Chemistry, University of Aberdeen, Aberdeen, UK
E-mail: h.deng@abdn.ac.uk

Abstract

A novel near-infrared fluorescent light-up probe with a tumor-homing pentapeptide, CREKA (Cys-Arg-Glu-Lys-Ala), specifically binds to fibrin–fibronectin complexes was rationally designed and developed for biomedical imaging. Its superior practical applications in tumor imaging and drug-induced liver injury detection are well demonstrated for the first time.

Chemical Communications

A novel near-infrared fluorescent light-up probe for tumor imaging and drug-induced liver injury detection†

Abstract

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A novel near-infrared fluorescent light-up probe for tumor imaging and drug-induced liver injury detection

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