Issue 15, 2018

Copper nitrate: a privileged reagent for organic synthesis

Abstract

Copper has been explored as an ideal candidate for replacing noble metals in organic synthesis, especially for practical large scale preparation. Recent decades have witnessed the renaissance and improvement of copper-catalyzed and copper-mediated organic reactions. Copper nitrate is a common inorganic copper salt which has been proved to be a ubiquitous reactant in organic synthesis due to its commercial availability, stability, inexpensiveness and environmentally benign nature. Copper nitrate could be used as a nitration reagent, oxidant, catalyst or promoter, and Lewis acid as well. Remarkably, great attention has been devoted to the efficient transformation of copper nitrate into functionalized or complicated compounds through various reaction types including cyclization, C–H activation, difunctionalization, nitration, rearrangement and asymmetric synthesis with chiral ligands. Further modification of copper nitrate, such as solid-supported copper nitrate or copper nitrate complexes, extends its applications in organic synthesis. The present review highlights recent advances of copper nitrate in organic synthesis, along with the mechanisms.

Graphical abstract: Copper nitrate: a privileged reagent for organic synthesis

Article information

Article type
Review Article
Submitted
08 Feb 2018
Accepted
12 Mar 2018
First published
14 Mar 2018

Org. Biomol. Chem., 2018,16, 2602-2618

Copper nitrate: a privileged reagent for organic synthesis

M. Gao, R. Ye, W. Shen and B. Xu, Org. Biomol. Chem., 2018, 16, 2602 DOI: 10.1039/C8OB00332G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements