Nickel-catalyzed cross-coupling of β-carbonyl alkenyl pivalates with arylzinc chlorides

Abstract

The nickel-catalyzed cross-coupling reaction of β-carbonyl alkenyl pivalates with arylzinc reagents generates 3-aryl-substituted α,β-unsaturated carbonyl compounds via C–O bond cleavage. The reaction features mild reaction conditions, a wide scope of substrates, and good functional group tolerance.