Issue 20, 2018

Syntheses, crystal structures, DNA binding, DNA cleavage and DFT study of Co(iii) complexes involving azo-appended Schiff base ligands

Abstract

Herein, we have reported three new Co(III) complexes involving azo-appended Schiff base ligands. All three complexes were characterized using different spectroscopic tools like NMR, FTIR and UV-Vis. The structures of the complexes 1–3, were confirmed by single crystal X-ray diffraction analysis. DFT and TDFFT computations were performed to support the structural and electronic parameters of the complexes. Computed bond distances and angles well resemble those of X-ray data. Absorption and viscometric titration studies revealed that each of these octahedral complexes interacts with CT DNA to result in minor groove binding. The intrinsic binding constants (Kb) were calculated to be 7.90 × 105, 1.35 × 105 and 1.075 × 105 M−1, respectively, for complexes 1–3. Complexes 1–3 also exhibited oxidative DNA cleavage activity in the presence of hydrogen peroxide.

Graphical abstract: Syntheses, crystal structures, DNA binding, DNA cleavage and DFT study of Co(iii) complexes involving azo-appended Schiff base ligands

Supplementary files

Article information

Article type
Paper
Submitted
07 May 2018
Accepted
30 Aug 2018
First published
30 Aug 2018

New J. Chem., 2018,42, 16571-16582

Syntheses, crystal structures, DNA binding, DNA cleavage and DFT study of Co(III) complexes involving azo-appended Schiff base ligands

S. Banerjee, R. Patra, P. Ghorai, P. Brandão, S. G. Chowdhury, P. Karmakar and A. Saha, New J. Chem., 2018, 42, 16571 DOI: 10.1039/C8NJ02235F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements