Using whole cells of Escherichia coli co-expressing alcohol dehydrogenase (PsADH) and formate dehydrogenase (CpFDH) in a biphasic aqueous–soybean oil system is shown to be an efficient method for the biosynthesis of enantiopure tolvaptan. In this system, (S)-tolvaptan with an optical purity of 99.5% and a bioconversion efficiency of 86.1% was achieved.
H. Zhang, C. Zhang, M. Han, C. Pei, Z. Xu and W. Li, Green Chem., 2018, 20, 1224 DOI: 10.1039/C7GC03679E
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