Copper-catalyzed oxidative intermolecular 1,2-alkylarylation of styrenes with ethers and indoles

Abstract

A new copper-catalyzed oxidative three-component intermolecular 1,2-alkylarylation of styrenes with ethers and indoles is disclosed. This method utilizes TBPB as an oxidant to efficiently construct C(sp³)–C(sp³) and C(sp³)–C(sp²) bonds in one step through probable radical and electrophilic alkylation processes, respectively, and a variety of functional groups are well tolerated.