Issue 55, 2018

C–H oxygenation at tertiary carbon centers using iodine oxidant

Abstract

An oxidation system in which iodic acid (HIO3) is used as an oxidant in the presence of N-hydroxyphthalimide (NHPI) permitted the selective hydroxylation of tertiary C–H bonds and the lactonization of carboxylic acids containing a tertiary carbon center. These reactions are operationally simple and proceed under metal-free conditions using commercially available reagents, thus offering an ideal tool for the efficient oxidation of C–H bonds at tertiary carbon centers.

Graphical abstract: C–H oxygenation at tertiary carbon centers using iodine oxidant

Supplementary files

Article information

Article type
Communication
Submitted
09 May 2018
Accepted
12 Jun 2018
First published
13 Jun 2018

Chem. Commun., 2018,54, 7609-7612

C–H oxygenation at tertiary carbon centers using iodine oxidant

K. Kiyokawa, R. Ito, K. Takemoto and S. Minakata, Chem. Commun., 2018, 54, 7609 DOI: 10.1039/C8CC03735C

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