A benzoic acid terpyridine-based cyclometalated iridium(III) complex as a two-photon fluorescence probe for imaging nuclear histidine

Qiong Zhang; Xin Lu; Hui Wang; Xiaohe Tian; Aidong Wang; Hongping Zhou; Jieying Wu; Yupeng Tian

doi:10.1039/C8CC00908B

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A benzoic acid terpyridine-based cyclometalated iridium(iii) complex as a two-photon fluorescence probe for imaging nuclear histidine†

Qiong Zhang,

‡^a Xin Lu,

‡^a Hui Wang,

‡^ab Xiaohe Tian,

*^c Aidong Wang,

^d Hongping Zhou,

^a Jieying Wu

^a and Yupeng Tian

*^ae

Author affiliations

* Corresponding authors

^a Department of Chemistry, Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Anhui University, Hefei 230601, P. R. China
E-mail: yptian@ahu.edu.cn

^b Department of Chemistry, Wannan Medical College, Wuhu 241002, P. R. China

^c School of Life Science, Anhui University, Hefei 230601, P. R. China
E-mail: xiaohe.t@ahu.edu.cn

^d School of Chemistry and Chemical Engineering, Huangshan University, Huangshan, P. R. China

^e State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, P. R. China

Abstract

A series of two-photon active cyclometalated iridium(III) complexes (Ir1, Ir2 and Ir3) were designed. Ir1 with a two-photon action cross-section of 40 GM in the NIR region has been developed for targeting intracellular histidine. Two-photon micrographs showed that Ir1 could rapidly and selectively light up the nucleus in both fixed and live cells and is capable of displaying nuclear histidine distribution in ultra-detail using a super resolution (SR) technique under stimulated emission depletion (STED) microscopy.

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DOI: https://doi.org/10.1039/C8CC00908B
Article type: Communication
Submitted: 02 Feb 2018
Accepted: 14 Mar 2018
First published: 20 Mar 2018

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Chem. Commun., 2018,54, 3771-3774

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A benzoic acid terpyridine-based cyclometalated iridium(III) complex as a two-photon fluorescence probe for imaging nuclear histidine

Q. Zhang, X. Lu, H. Wang, X. Tian, A. Wang, H. Zhou, J. Wu and Y. Tian, Chem. Commun., 2018, 54, 3771 DOI: 10.1039/C8CC00908B

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Chemical Communications

A benzoic acid terpyridine-based cyclometalated iridium(iii) complex as a two-photon fluorescence probe for imaging nuclear histidine†

Abstract

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A benzoic acid terpyridine-based cyclometalated iridium(III) complex as a two-photon fluorescence probe for imaging nuclear histidine

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