Issue 27, 2017

A Pd-catalyzed, boron ester-mediated, reductive cross-coupling of two aryl halides to synthesize tricyclic biaryls

Abstract

Tricyclic biaryls are important scaffold structures in many natural products and lead compounds in drug discovery. The formation of a biaryl unit is often the key step for the synthesis of tricyclic biaryls. Despite significant progress toward the synthesis of biaryl compounds in recent years, the direct cross-coupling of two different aryl halides is still challenging and robust methods are lacking. Herein we report a direct cross-coupling of two different aryl halides in the presence of a palladium catalyst and boron ester, which provides a new and useful complementary method to synthesize tricyclic biaryls.

Graphical abstract: A Pd-catalyzed, boron ester-mediated, reductive cross-coupling of two aryl halides to synthesize tricyclic biaryls

Supplementary files

Article information

Article type
Paper
Submitted
19 May 2017
Accepted
16 Jun 2017
First published
20 Jun 2017

Org. Biomol. Chem., 2017,15, 5790-5796

A Pd-catalyzed, boron ester-mediated, reductive cross-coupling of two aryl halides to synthesize tricyclic biaryls

Z. Chen and X. Wang, Org. Biomol. Chem., 2017, 15, 5790 DOI: 10.1039/C7OB01237C

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