Issue 18, 2017
From the journal:

Chemical Communications

X-ray crystallographic structure of a teixobactin analogue reveals key interactions of the teixobactin pharmacophore†

H. Yang, ORCID logo a   D. R. Du Bois,a   J. W. Zillera  and  J. S. Nowick*a  

* Corresponding authors

a Department of Chemistry, University of California, Irvine, Irvine, California 92697-2025, USA
E-mail: jsnowick@uci.edu

Abstract

The X-ray crystallographic structure of a truncated teixobactin analogue reveals hydrogen-bonding and hydrophobic interactions and a cavity that binds a chloride anion. Minimum inhibitory concentration (MIC) assays against Gram-positive bacteria correlate the observed structure with antibiotic activity.

Graphical abstract: X-ray crystallographic structure of a teixobactin analogue reveals key interactions of the teixobactin pharmacophore

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Article information

DOI
https://doi.org/10.1039/C7CC00783C
Article type
Communication
Submitted
30 Jan 2017
Accepted
10 Feb 2017
First published
13 Feb 2017

Chem. Commun., 2017,53, 2772-2775

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X-ray crystallographic structure of a teixobactin analogue reveals key interactions of the teixobactin pharmacophore

H. Yang, D. R. Du Bois, J. W. Ziller and J. S. Nowick, Chem. Commun., 2017, 53, 2772 DOI: 10.1039/C7CC00783C

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