Issue 11, 2017

Efficient activation of a visible light-activatable CA4 prodrug through intermolecular photo-unclick chemistry in mitochondria

Abstract

Photo-unclick chemistry mediates visible and near IR-controlled drug release via a singlet oxygen (SO)-cleavable linker. Due to the limited diffusion distance of SO in biological systems, a photosensitizer and the SO-cleavable linker have been conjugated in one molecule or mixed in nano-drug delivery systems. In this communication, we demonstrate a new strategy to activate prodrugs with photo-unclick chemistry in an intermolecular fashion using an SO-cleavable CA4 prodrug and a mitochondria-specific photosensitizer, protoporphyrin IX, formed from prodrug hexyl-5-aminolevulinate.

Graphical abstract: Efficient activation of a visible light-activatable CA4 prodrug through intermolecular photo-unclick chemistry in mitochondria

Supplementary files

Article information

Article type
Communication
Submitted
15 Dec 2016
Accepted
16 Jan 2017
First published
17 Jan 2017

Chem. Commun., 2017,53, 1884-1887

Efficient activation of a visible light-activatable CA4 prodrug through intermolecular photo-unclick chemistry in mitochondria

M. Bio, P. Rajaputra, I. Lim, P. Thapa, B. Tienabeso, R. E. Hurst and Y. You, Chem. Commun., 2017, 53, 1884 DOI: 10.1039/C6CC09994G

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