Photo-induced synthesis and in vitro antitumor activity of Fenestin A analogs

Abstract

Two novel Fenestin A analogs (1 and 2) containing a phthalimide moiety are prepared by photoinduced cyclization. Their absolute configurations were determined by experimental ECD with the aid of theoretical calculations. The resulting compounds are active in HeLa (IC₅₀ = 28.2 μM for 1 and 36.5 μM for 2) and HepG-2 cell lines (IC₅₀ = 33.5 μM for 1 and 40.3 μM for 2).