Vasorelaxant activity of twenty-one physiologically relevant (poly)phenolic metabolites on isolated mouse arteries
E.
Van Rymenant, 
ab
C.
Grootaert,
a
P. W.
Needs,
c
P. A.
Kroon,
c
A.
Kerimi,
d
G.
Williamson,
d
A.
González-Sarrías,
e
F.
Tomas-Barberan,
e
J.
Van de Voorde
*b
ab
C.
Grootaert,
a
P. W.
Needs,
c
P. A.
Kroon,
c
A.
Kerimi,
d
G.
Williamson,
d
A.
González-Sarrías,
e
F.
Tomas-Barberan,
e
J.
Van de Voorde
*b
Abstract
Polyphenols are beneficial for health, but are metabolised after consumption. We compared the vasorelaxant capacity of twenty-one physiologically relevant polyphenol metabolites in isolated mouse arteries. Hesperetin, urolithins and ferulic acid-4-O-sulfate – not their glucuronidated forms or ferulic acid – caused vasorelaxation. Therefore, we advise the use of relevant conjugates in future mechanistic research.
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