Triple function nanocomposites of porous silica-CoFe2O4-MWCNTs as a carrier for pH-sensitive anti-cancer drug controlled delivery

Abstract

Cobalt ferrite nanoparticles loaded on multiwalled carbon nanotube (MWCNT) magnetic hybrids have been demonstrated to be promising magnetic resonance imaging contrast agents and drug carriers. However, the hydrophobic, less biocompatible characteristics and low loading capacity for the drug hamper their wide biological applications. To solve the above problem, an alternative strategy is to coat the MWCNTs@CoFe₂O₄ nanoparticles with a mesoporous silica (mSiO₂) shell. Herein, the reasonable fabrication process results in successful coating mSiO₂ on the as-obtained MWCNTs@CoFe₂O₄ nanoparticles, forming well-defined core–shell-structured MWCNTs@CoFe₂O₄@mSiO₂ nanocomposites. The as-synthesized mesoporous nanocarrier possesses a high surface area and large pore volume for the loading of the drug, and has a superparamagnetic feature for drug targeting. Moreover, the anticancer drug doxorubicin (DOX)-loaded MWCNTs@CoFe₂O₄@mSiO₂ nanoplatforms show an excellent pH-responsive drug release character within 48 h. Therefore, a novel nanocarrier based on MWCNTs@CoFe₂O₄@mSiO₂ was proposed, and its potential application for targeted cancer therapy was highlighted.